Eradication Rates of Clarithromycin Triple Therapy in Korea: A Systematic Review and Meta-analysis

Background/Aims: Standard triple therapy, including a proton pump inhibitor, clarithromycin, and amoxicillin, has been recommended as the first-line for <i>Helicobacter pylori</i> infection. However, eradication rate of standard therapy declined over past years because increasing resistance to clarithromycin in Korea. We analyzed rates 10-year change Korea.Methods: PubMed, EMBASE, Cochrane Library, KoreaMed were searched studies published between January 2007 June 2018. The pooled their 95% CIs estimated using random-effect logistic regression model.Results: Twenty-six randomized controlled on conducted Korea selected. intention-to-treat (ITT) per protocol analyses showed 71.6% (95% CI, 69.9~73.3%) 79.6% 76.6~82.2%), respectively. decreased with time. ITT analysis that 14-day (78.1% [95% 75.2~80.7%]) had significantly higher than 7-day (70.0% 68.5~71.4%]) (<i>P</i><0.01).Conclusions: These results suggest shown an unacceptable decrease. increased when duration was 14 days, but it not satisfactory. Therefore, other treatment regimens or therapies based susceptibility tests should be considered therapy.